化苑讲坛第636期

报告题目：Roles of Distinct Chemical Factors in Hydrolysis Catalyzed by Metalloenzymes and their Synthetic Analogues

报告人：Prof. Rajeev Prabhakar

报告时间：2023年5月19日（周五）上午9:00-11:30

报告地点：东三楼321会议室

个人简介：

Prof. Rajeev Prabhakar 现就职于University of Miami, Department of Chemistry. 1993年和1995年先后于Meerut University获Physics, Chemistry, Math学士学位和Physics硕士学位，2003年于Stockholm University获Quantum Chemistry博士学位。2006年在Emory University完成博士后工作，同年起于University of Miami, Department of Chemistry任教授至今。迄今共在一线学术期刊发表论文96篇，受邀参加学术会议73次。2021年至今任期刊Frontiers in Chemistry(IF=5.22)副主编，“Development of Synthetic Analogues of Metalloenzymes”特刊特约编辑。曾于2007年获西班牙政府颁发的国际奖项，受邀访问并担任三所高校与研究所的客座教授；同年获the Japan Society for the Promotion of Science (JSPS)受邀访问六所高校和研究所并担任客座教授。另获Wiley Young Investigator Award.

报告简介：

The selective hydrolysis of the extremely stable phosphoester, peptide and ester bonds of molecules by bio-inspired metal-based catalysts is required in a wide range of biological, biotechnological and industrial applications. Despite the impressive advances made in the field, the ultimate goal of designing efficient synthetic analogues of enzymes for these reactions is still elusive. The existing analogues include both peptidic and non-peptidic compounds. However, due to their structural simplicity they are significantly less efficient than natural enzymes. The development of the next generation of analogues will require a deeper understanding and fusion of diverse chemical factors that influence activities of both natural and synthetic catalysts. They include catalyst-substrate complexation, non-covalent interactions and the electronic nature of the metal ion, ligand environment and nucleophile. Based on our studies, their roles will be discussed for several mono- and binuclear metalloenzymes and their synthetic analogues.