香港大学孙红哲教授做客第271期化苑讲坛

 报告题目：Integrative-omics approach for metals in medicine

报 告 人 ：孙红哲教授

报告时间：2017年6月16日（周五）下午15:00

报告地点：化学楼二楼一号会议室

邀 请 人 ：刘红梅教授

报告人简介：

    孙红哲教授，1996年获伦敦大学博士学位，现为香港大学化学系教授、博导，中山大学“计划”获得者、国家杰出青年基金获得者，先后荣获香港裘槎基金会“裘槎杰出研究者奖”、香港大学杰出研究者奖以及香港大学杰出研究生导师奖。主要从事化学与生物、医学的交叉前沿研究，擅长生物无机化学、金属组学/金属蛋白质组学及金属蛋白质的结构生物学。迄今发表论文150余篇，总引用达6000余次，h因子大于43。

报告内容：

    Metal ions play crucial roles in life processes either as an essential elements or therapeutical/diagnostic agents. It is crucial to identify metal-protein interactions at a proteome-wide scale which are difficult due to certain weak and transient interactions. We developed an integrated approach consisting of gel electrophoresis and inductively coupled plasma mass spectrometry, immobilized metal affinity chromatography (IMAC), fluorescence and bioinformatics to identify metal-associated proteins using bismuth antiulcer drug as an example. We have identified metal-associated proteins as well as to quantify the metals for fast metallome/proteome-wide profiling of metal-binding proteins. The multi-targets of bismuth(III) provide a rational basis in understanding the high efficacy and low antibiotic resistance of this class of bismuth drugs. We also show that an integrative metallomic approach represents a powerful tool for metals in biology and medicine as well as pharmacology of metallodrugs.