报告题目：Function-Driven Divergent and Efficient Synthesis of

Bioactive Molecules

报 告 人 ：Mingji Dai 教授

报告时间：2018年5月22日（周二）上午10:00

报告地点：东三楼321会议室

邀 请 人 ：吴雪松 教授

报告人简介：

Mingji Dai grew up in Sichuan Pengzhou and received his B.S. degree from Peking University in 2002. After two years’ research with Professors Zhen Yang and Jiahua Chen in the same university, he went to New York in 2004 and pursued graduate study under the guidance of Professor Samuel J. Danishefsky. After earning his Ph.D. degree in 2009, he took a postdoctoral position in the laboratory of Professor Stuart L. Schreiber at Harvard University and the Broad Institute. In the August of 2012, he began his independent career as an assistant professor in the Chemistry Department of Purdue University. His lab currently focuses on developing new strategies and methodologies for the synthesis of complex natural products and other medicinally and biologically important molecules.

报告简介：

This talk will highlight elements of our recent efforts in developing novel strategies and methodologies for divergent and efficient synthesis of medicinally important molecules. Particular emphasis will be placed on our research program in developing functional-group-pairing (FGP) strategies for divergent total synthesis of neurologically active alkaloids and tandem catalytic transformations for efficient total synthesis of anticancer macrolides, spirocyclic natural products, and polycyclic diterpenes. Additionally, a novel amphoteric diamination method toward privileged 1,4-diazo heterocycles in medicine will be discussed. Accompanying the synthesis, the corresponding evaluations of the target molecules’ biological function will be discussed as well.